I do it for fun. Get gloves of the puglist from the ratway in riften, that would be the first thing i do.
And since there isn't no unarmed skill tree focus on getting enchantments that help with unarmed. Disenchanting the gloves, and then enchanting rings, necklaces, gauntlets, etc.
So really I would go with the enchanting skill tree. And I don't think there are any skills at all that help with unarmed but then again I haven't played in a while.