They aren't worth anything later, are they? We are not talking about Super Nintendo games or FFVII here. I tend to buy CEs of games I have a really good feeling I will enjoy and just keep good care of them. I don't really see FO:NV becoming an "OMG, look what I have in the attic" Eleventy-billion dollara super find. I opened my CE and am enjoying it thoroughly. I suggest you do the same.
I wonder if the original purchasers for these SNES or FFVII carts or memorabilia had this in mind when they first purchased their items. When Final Fantasy was selling well in the Electronics Botique I bought FFVII at, I picked up a few of the 'action figures' that represented the game. Namely a Vincent and a Sephiroth. They had all the little pieces that went with their characters and were sealed with clear plastic tape to their card displays that were printed in the obviously imported Kanji or Katikana or what have you. I put the figurines away and checked again in 10 years to see what the accrual on their value was. For the Sephiroth, it was being sold for around 50 dollars last I checked.
With the hassle of finding a buyer, shipping and the pitfalls that can occur in any cash transaction, I eventually gifted it to a family member who was developing an interest in anime and art in general.
I guess where I'm going with this is you can set things aside and keep them mint-in box. But the extra bit of money that sacrifice may bring your way ultimately isn't worth what you will have missed out on by not experiencing the charm of the content you purchased in the first place. For me, the 'purchased as an investment' mentality I took towards the action figures ultimately left me detached from the purchase in the first place. I couldn't appreciate their value, as it had very little other than an investment for me, which is why it was so easy to just gift it away.
In my opinion, you would be better off to enjoy what you have than to squirrel it away on the slim chance that one day, every other copy of the collector's edition were to be destroyed, leaving yours as the last copy on Earth.