PC version, *checks* 9.5 hours. I haven't been taking note of bugs, but here are the ones I remember, in no particular order.
1) I'm experiencing the Quicksave problem too. I made one at the beginning of the game, in Doc Mitchell's house, and that's the only quicksave the game will make or recognize. It is always treated as my most recent save (e.g., if I select Continue, it will always go to that) and cannot be overwritten. My manual saves work perfectly well, however, and I always had a habit of making hard saves in FO3 anyway so this doesn't bother me much. If they patch it up soon, then yay.
2) I haven't experienced the massive framerate drops that some people have described, but I do get significant drops in populated areas. It seems that just facing a group of NPCs can bring it on, while turning away from them (while still being in the same room) will bring the framerate back up. This is probably the only thing I've encountered so far that bothers me, but I'm sure they can patch it easily enough (it's probably just something with the way the game handles NPC scripts or something).
3) Once, in the saloon in Goodsprings, one of the patrons was stuck in the counter.
4) Once, I killed a Mole Rat Pup and as it died in slow-mo, it sank into the ground and I watched it fall into a glitchy abyss.
5) In a house in Nipton, some bottles on a table were floating in the air (okay, I'm kind of reaching at this point; this was probably just an object placement error, unless nobody else has the same thing).
Not very many glitches at all, all things considered. No CTDs, no glitched textures, no broken games. I'm very pleased. What makes me curious is why some people are experiencing these issues (some of which can't be easily ascribed to the computer, I think) while others aren't.