Anyone else having this problem?

On the PC version, I can't hear the opening "war never changes commentary." In the game, I often can't hear an NPC dialog because its mixed in with background noise or music (I'm very greatfull for the subtitles!) I cannot make out most of what's on the radio stations. I have gone to the options screen and worked the audio sliders, but I still can't get the music, noises, and character voices to become distinct. I didn't have this problem with FO3, which I am also still playing, so its not my rig. What changed in audio from FO3 to FONV?

Nothing, as far as I know. Have you looked at your rig's sound manager?

if u have a surround sound system set up, play around with it......same thing happened with me...i had it set up as 5.1 but for the game it has to be set up as quadapholic or something like that

If you have surround sound that supports Matrix mode disable it... i had it on and could not hear certain sounds such as footsteps,talking etc.. after disabling matrix mode on my surround sound it all worked out fine.