Did you make any system changes recently? Or in-game changes like mods?
Edit: Just understood what you said about the sound. This might not be what you're talking about, but then again it might help. Why it starts, nobody knows, but if it works for you, then awesome. http://crashfixes.com/fixing-skyrim-crashes-freezes-errors-steam-crash-no-sound-lags-choppy-framerates/
Scroll down to where it says something about crashes, sound files, and all that. For some reason some people experience crashes related to their sound files, and there's a fix there. It might help you out.
Edit 2: "Fixing Skyrim Crashes, Freezes, Errors, Steam crash, No Sound, Lags, Choppy framerates" is the heading I'm talking about, under that those fixed might help you out some.
Your link does not working for me if you could copy-paste here then I'll be grateful , if you mean fixing sound :
Click Start | Control Panel.
Click Hardware and Sound| Sound.
Under Playback tab, select your speaker, and click Properties button.
Click Advanced tab.
Select this option: 24 bit, 48000 Hz or 24 bit, 44100 Hz (Studio Quality), and then click OK
this didn't helped me .
yes i had few mods ,maybe three and everything worked fine. and then from nowhere game started crash in the specific places(non of those three mods were deleted they were all the time,i think mods are not the reason ) . i found in other forums that i am not the only one who having these crashes in specific places like Markarth . it can't be mods . i had heavy modded oblivion and fallout but never had problem like now with skyrim. i had no system changes just played like a maniac and then first time i notice near riften,jumped over that place with fast traveling and then same problem started in another cities .