Honestly don't think this is a good idea. Basically forcing people into having to play an Orc (I'm assuming thats what would happen) would ruin the game. Carrying Capacity is a big deal, what is there to say that Orcs are the strongest race? If you implemented this idea, then what about females, wouldn't you have to nerf their CC even further? The CC is fine as it is, & if it bothers you, then you could just make up an entertaining back story as to why you can carry so much or even place a limit on what YOU think you should be able to carry, something akin to a DiD playthrough.
Eh jumping draining fatigue? That doesn't sound too bad, but would again limit the gameplay & take it from a casual game to something extreme & IMO once again, Not very fun.
These would be excellent ideas for something like a FO:NV hardcoe mode. It'd make the game alot more interesting having to worry about CC & Fatigue more openly.