I would depend. Daedric bow with glass arrows if long or medium distance. Daedric Dagger in right hand & either Close Wound or Wall of Storms in left hand. Even though my Block is 100, I don't use a shield or block as I can attack multiple times in the time it takes to block. Elemental Fury or Slow Time comes in handy.
Nord Hero's Blade in right hand and Dawnbreaker in left hand, Ancient Nord arrows equipped. Bow and restoration spell are only a key away after all. Oh, and Kyne's Peace if it happens to be an animal.