On the contrary, a reasonable player who plays in DiD mode will invest a lot more on health so that at least he does not get one shot. If something does not one-shot you, you can in theory survive the battle by healing yourself before you get hit the second time, as long as you have enough potions or magicka. I imagine the situation like that will be a lot more exciting for a DiD player, while a normal player would just get annoyed by having to reload 50 times.
I play on master, but I RP so using potions mid battle would be a definite no no for me. Guess healing is an option, and one i use within my RP.
But so much is going to whoop your behind, bears, ice wolves, saber cats... not to mention dungeons. An to be honest your not going to be able to stack health quick enough, could end up being extremely frustrating.