Desert Eagle .44 Magnum, chrome plated. With upgrades available, 10" barrel, extended mag, scope... Sweet domination!

and

Desert Eagle .50 AE, Gold plated as "unique" variant.

Give em a lil perk too, penetration, being able to pass through one target and into another behind it; through wood and thin metal as well.

While I'm not huge on real word weapons created after the timeline diverged, I'd like to see the http://en.wikipedia.org/wiki/Bren_Ten in game as a nonfunctional weapon, saying something in the weapon description about it being in perfect condition, expect for the missing magazine...

@Shay: If you want a handgun famed for overkill, only with a touch of class, check out the http://en.wikipedia.org/wiki/Colt_Delta_Elite. The FBI carried them briefly, but had to stop because of their penchant for over-penetration. Classic design with a severe punch, and you won't be mistaken for a cross-eyed pimp for carrying it.

How could I forget. I want to have a .50 cal Machine gun like the http://fallout.wikia.com/wiki/Browning_M2. It's been around since the early 1930's and no sign of it being replaced in are timeline anytime soon.

The game is already going to have .50 cal sniper rifles so if there is no machine gun

I don't play to much CoD, I happen to be a WW1 and WW2 enthusiast and I enjoy the weapons of that era is it so much for me to want weapons I have studied & loved for so long?

Not to mention they're better then half of the more modern weapons by far in my opinion at least.

Also I heard a MG42 mentioned and that would be awesome! Who doesn't want a Light Machine Gun with up to 1,500 rounds per minute! (Might have to be its modern predecessor the MG3 currently in service with the Bundeswehr)

I want a Chauchet, It would make an excellent decoration, or perhaps a conversation piece. Maybe even mailing it to someone in order to send a message?

The Chauchet the weapon notorious for its abundance of stoppages and jams especially in the trenches of World War 1

One of the French's not-so-good weapons (It seems like they didn't make a whole lot of half decent weapons until the MAT-49 or FAMAS came around which I praise highly for its high rate of fire and wonderful bullpup design)

Electric Chain Gun, an energy weapon that fires out a constant beam of electricity, if there are multiple hostiles close together they all share the electric damage.

Napalm Caster, this energy weapon casts a napalm rain in a linear AOE effect towards the enemies and stays on the ground and continues to burn for 20 seconds.
Unlike the flamer it casts a constant burst for 3.5 seconds so once you press the trigger it will keep on firing for 3.5 seconds even if your character dies. you cannot start a burst and go into VATS precisely after either.

Heat Emitter, this energy weapon is a big gun, to the size of the flamer, it casts a heat wave in a 140 degree aoe angle 3 meters towards enemies, it takes a couple of seconds to charge up and has a continuous damage.

Glass Rifle, the glass rifle is an energy weapon that heats sand to such high temperature that it crystalize to glass, it then blasts the heated glass fragments out like a shotgun, first the user needs to reload it then let it crystalize the sand.

Acid Blaster, the acid blaster is a plasma rifle sized weapon that blasts out a large amount of acid which will eat away at armor and weapons really fast.
It's acid that it casts out are not projectiles that will fly very far though and is meant for close range, unless you're really good with mortars.

I'm digging the Electric Chain Gun and Napalm Caster they sound badass.

Those sound like really cool ideas
I like the Glass Rifle

EDIT: I want to see an energy weapon variant of the sniper rifle

Nail gun
a reqular spear
a bomarang (only able to come back if u get a perk learned from a tribal)
throwing knife, tomahawks and sling shots that shoot small marbales or a glass ball filled with gas or acid eats at armour
or people if wearing clothes
and a fev sprayer cuz still sounds amazing even without a lot of ammo but how would the muties turn people without it so go to SM find the room were they mutate people and steal it or off SM bodies cuz they be the ones using

Pneumatic weapons like those in Metro 2033; kinda surprised we haven't seen pneumatics yet in Fallout.

If your going to have the beautifully crafted M1 Garand why not have its little brother the M1 Carbine or even better the improved M2 Carbine that had selective fire capabilities meaning lots of bullets down range?

It fires the .30 Cal Carbine Rounds:
http://deuce45s.com/images/30%20Carbine%20Tracer%20Ammo.jpg

Here's the M2 Carbine:
http://www.wwiiguns.com/store/images/m2carbine_modelgun_store2_wwii_0906_5fa.jpg

Gauss Rifle.
Wait, just looked it up, I was way off.

On that note, more weapons that uses a series of electromagnetic fields to propel rounds at tremendous speed.
But if it's more than 6 then I want a new skill for them.

I hope this counts even though it's a return, but I'd like to see the Red Ryder LE again.

take a look at these links: http://fallout.wikia.com/wiki/Pancor_Jackhammer#Pancor_Jackhammer

http://fallout.wikia.com/wiki/P90

http://fallout.wikia.com/wiki/Desert_Eagle

Any gun i'd want in this game wouldnt be real, but the M82A2 could be a good contender against the Anti Material Rifle, and the All American.

a jack hammer and a regular hammer like the to pull out and push nails in

Rifle sized Rail Gun that fires fully automatic.

Nail Bombs

Willy Pete

Battle Axe

Shoulder mounted cannon

Time Warping cannon (as in when hit by it, it sends you back through time 500 million years)

The Bozar was an absolute beast in Fallout 2- the perfect mixture of heavy damage, armor penetration and accuracy. The Vindicator/Avenger miniguns edged over it later on, but they chewed up so much ammo that it really wasn't worth it to rely on them. It was made more memorable by the fact that it was virtually impossible to find on NPCs outside of a specific small group of merchant guards, all of whom could have it stolen from them.

Another awesome gun which nobody has mentioned here is the http://fallout.wikia.com/wiki/Neostead_Combat_SG, which was an excellent mid-tier automatic shotgun in Fallout Tactics. You can see it's real life equivalent in action here: http://www.youtube.com/watch?v=d-EiFtypUfQ

The return of the Rock-It launcher with new junk items to load it with.
Bags of rhinestones that brake open when fired or velvet paintings of molerats playing cards.
Skulls with Elvis wigs on them.
Decks of playing cards.
Shotglasses that have viva New Vegas written on them with a sharpy.
Some of those cheesy metal straws you can get in Vegas.
Coffee cups with the game designers first names on them and the old pre-war Vegas labels on them.
Elvis Teddy bears.
Toy motorcycles and 50's era biker action figures.
And so on...

Frag Launcher, it launches a frag grenade it primes it so they expldoe 3 seconds early like a shotgun. in the air.

lots, lots more melee weapons.