I have a digital Matrox triplehead2go connected to 3 22" monitors with a combined screen resolution of 3840 X 1024. I have made adustments to the
FalloutPrefs.ini file
iSize W=3840
iSize H=1024
My screen appears to be working properly until I open a computer in the game and then I can't see the entire ingame computer screen...What do I need to
change for this issue.

This game is buggy to begin with and I doubt multiscreens are supported. I wish I could help but you best bet is a mod in the future or a decent patch.

Here is the Multimonitor Thread:
http://www.gamesas.com/index.php?/topic/1122530-multi-screen-resolution-support/