I recently updated my game to build 1.2.0.310, everything seemed to work fine until recently, now if i even think about touching the d-pad to use the hot-key system the game locks up with no chance of retrieval. It also does it if i press the button to bring up the hot key menu while in the pip-boy,

I had tried a great many things in my newer saved game in order to correct this issue including waiting 24 hours waiting 12 hours (incase it was a lighting gfx glitch), changing my area, buying different/more ammo. etc etc. Ultimately the problem went away when i offloaded everything in my inventory as to force clear my hot keys and then put everything back in.

One strange possibly unrelated note is that after retrieving my full inventory again but before beginning to hot key items again I brought up the hot key menu and everything was gone from it (as expected) except the frag grenades, it didnt freeze anymore but im 100% positive they were removed from my inventory so they should not have automatically returned to there hot key spot. I never checked to see if they were removed from the hot keys while not in my inventory however.

I hope all of this helps, I always try to gather AS MUCH information as possible when reporting bugs as I know it could be anything little thing creating the problem (such as a crows position relative to the position of sun casting a shadow in a specific spot causing a glitch.