With the most recent report I've had, the person says that it starts up fine if they're starting a new game ...So a dirty save maybe?
That's basically the acid test (though not foolproof) ... if it does not run from a save, but does from a new game, then it's usually a dirty save (either from a previous release of your stuff, or to do with the editing of a vanilla script).
It's a little bit odd to see it if you have not made an amendment to vanilla that effects your quest start, though ... Have you released a previous version?
If not ... There is a chance that - because FRAGMENTS are "random named" by default - another mod has the same script name as yours - You can get around that by using Preferences in the CK and adding a prefix (I forget which tab, but there aren't that many), so that all scripts you make have more chance of being uniquely named
Then it depends on load order of each client (I think) - how Load Order is calculated has changed, which ups the ante a bit for conflicts ... There's a topic on that in the mods forum (linked from a recent post on here too ... but I can't find that now). Last I saw, most Mod Managers weren't complaint with the new way of doing stuff (patch two days ago)
Best of luck ... It's going to be a nightmare, is this ...