I have read that ED-E could have been a reference to the movie Stealth; where there was the unmanned EDI who also had a spherical processor.

Although I confess I've never seen the movie, it does sound possible.
ED-E stands for Eyebot (Duraframe) – Subject E
could be a coincidence references everywhere
The name supports my theory, in my opinion. Eyebot (Duraframe) doesn't have any particular significance, and the name could have been shortened to a multitude of other acronyms.
Off topic: Everyone, stay calm and don't break any rules. They're... watching us....