One of the problems has already appeared: When you install the Creation Kit, the Data\Scripts\Source folder is populated with the PSC source code files for the stock PEX scripts.
Unfortunately, however, these PSC files don't appear to have been updated since the 11-11-11 release. For any that have been edited in official patches, the existing PSC source is out of date. For 7 scripts that were added by patches, there is no source code at all.
The following scripts were changed in one of the the official patches and it doesn't appear that their PSCs were updated. Therefore recompiling them can overwrite existing fixes and cause bugs:
c05questscript.pscda02bookscript.pscda02script.pscda07questscript.pscmg06armillaryscript.pscmgrapponmund1questscript.pscmgrarniel03scontainerscript.pscmonitoralivecountscript.pscmq302script.pscms11questscript.pscms12bquestscript.pscplayerbookshelfcontainerscript.pscqf_bardscollegedrum_000d944f.pscqf_bardscollegeflute_000d9431.pscqf_bardscollegelute_000d93fa.pscqf_da02_0004d8d6.pscqf_mgrapponmund01_0006bc33.pscqf_mq302_00045923.pscqf_ms01guardambushquest_000210cd.pscqf_ms02_00040a5e.pscqf_ms11_0001f7a3.pscqf_ms11kicker_000bac24.pscqf_ms12b_0002499c.pscreanimateashpile.pscsf_ms11calixtoattacklastvicti_0002b09b.pscsf_ms11openingcrimescene_000206ae.pscsf_tg00distractionsetupscene_00020e0a.psctif__00092a41.psctif__0009cccb.pscweaponrackactivatescript.pscweaponracktriggerscript.psc
As well, the following scripts' PSC source files were never added to Data\Scripts\Source so there is no source code for them, thus they cannot be easily edited:
c05repaircheck.pexda02fixstagescript.pexda07altaraliasscript.pexdefaultoncellattachenable.pexdunda14portaldisablescript.pexqf_patch1_4_updatequest_01000803.pextg09dooroverridefixscript.pex
Their PAS assembly code can be extracted using PapyrusAssembler {scriptname_without_pex_extension} -D. As far as I know, the only way to edit them is a hex editor.
I'm hoping that the updated PSC source code will be included in the next release of the Creation Kit. I did advise the developers prior to release...

