If your on patch 1.6, I would uninstall USKP, its ha been confirmed to break quests due to dialogue issues.
Glad to hear you can launch. Regarding cell resets, to do it properly, you have to wait 31 days in a cell that is totally divorced from the worldspace, and is flagged "never resets". The easiest place is breezehome in whiterun. If you have not yet bought it, or cant get there because of crashes, use console commands. You can find the commands online easily on how to teleport to inside breezehome.
Alright I'll try that, thanks.
EDIT: I slept over 31 days in Breezehome, teleported back to Whiterun and after saving there the size went down from 72,3 to 67,5 Mb.
Freezing is still there, loading takes long, saving takes long and uh.. also Vilkas or the guy who checks if you're worthy enough to join the Companions keeps opening a dialogue with me at the place where the lagging started when I sort of killed him.