I just got this side quest and whenever i try to talk to sapphire, she only says "I have no business with you". Any help would be appreciated.

try reloading a save. or, exit the tavern and go back in. sounds like the quest didn't fully register that you talked to shadr.

Alright. I'll try that.

Solution from "elderscrolls.wikia.com":

"Sometimes the player cannot talk to Sapphire after accepting the quest from Shadr. She will just continue to say "I have no business with you". There is currently no known fix. However, this may be caused by originally not offering to help Shadr, then changing your mind and accepting the quest the second time. In one case, reloading a game saved prior to speaking with Shadr and offering to help avoided the issue; Edit:You can get around Sapphire's bug by using the following two commands on her addfac 19809 1, setrelationshiprank player 4 then wearing the Amulet of Mara; this will force a dialog with her then you can find the dialog option to complete the bugged quest; this method can be used to fix similar bugs like the one with Illia."