This is really a discussion to have in the http://www.gamesas.com/topic/1356343-wipz-skyrim-script-extender-skse/, or perhaps in the CK forum.
Right now SKSE provides extensions to Scaleform used in UI modding, and the ability to create a C++ plugin to make changes. We are currently working on Papyrus extensions, and are close to having those ready. The Scaleform functions provided are documented in skse_docs.txt. SkyUI is probably your best example of usage (though really it amounts to asking us to inject information into Scaleform menus and then use that info as normal in Scaleform.) As for SKSE plugins, you can look at the community uncapper for an example there. However, that is very much like working on SKSE itself - dropping right to the core and using memory addresses.
Really I imagine what you want are the extensions to Papyrus that you can see listed in the first post of the SKSE thread. We are working on them and taking additional requests.