Twice already I have experienced a unusual problem. When entering a building, the interior sorta collapses in on itself. Pancaking everything together and causing the game to freeze up. Neither loading a prior save game or waiting for 3 in game days, will reset the cell. It just stays like that. Making it impossible to enter the building. Only starting a new game seems to reset the cell. It sometimes will pancake all the enemies in the building together in one big giant blob, right in front of the door. Also causing it to lock up. Has anyone else experienced this, or know a solution. Or perhaps a way I can reset the cell to normal other than what I have already tried.

Post a dxdiag please. If you have a 64-bit OS post a 64-bit dxdiag
http://www.gamesas.com/index.php?/topic/1122570-how-to-dxdiag/

Are you using mods?
Does this happen with other games?
How often does it happen?
Is this recent?

post as much info about the issue as you can (in as much detail as you can).