I made a mod that makes unarmed damage scale with your one handed skill, and also makes a particular weapon (which when equipped gets your dukes out) grant One-Handed exp and benefit from the perks of One Handed. I also added some disarm perks. Unforuntately now EVERYTHING wants to use unarmed attacks, even when their weapons would do more damage, and I've no idea why. I don't have more information really, if no one has any suggestions I will upload my mod as a beta and ask for someone to take a look maybe. I dunno, I'm pretty stunped.

EDIT: Of course after posting I immediately figure it out. Earlier when I was messing with the Unarmed weapon I had set its damage to 99 as an experiment, and had forgotten to set it back. Durr.