According to the most recent issue of game informer the recorded speed run time of the main quest line
is 2h 16m 10s by Sam Bernstein.

Anyone have a better time than this?

I am experimenting with different means on quickly getting through the storyline but I haven't beaten this time

I think the speed run should be how long it takes to do every quest in the game!! Haha that might take a while..

give me some feed back