I'd definitely be OK with bullet drop and an AI overhaul. Poor creatures and raiders don't stand a chance when you use suppressed weapons. I remember in FO3, when WMK (which added weapon suppression beyond the pathetic silenced 10mm pistol), I thought to myself "well, the AI wasn't really programmed with a suppressed sniper rifle shot from 5 cells over in mind." I was hoping, since powerful, suppressed weapons and the means to make them were in vanilla FNV, that the AI would be made aware of such things. Sadly... but AI is quite challenging to make (well,
good AI is, at least), so its up to the modding community to enhance the game! Like we've been doing since the day after launch!

All of the other stuff - coriolis, curvature, etc., is probably too much for the aged Gamebryo engine to handle.