One thing:
Inventory tabs on storage... In Oblivion I needed (personal preference) One chest for apparel, one for weapons and one for the rest.. Now I have to walk and carefully use all of my storage containers to keep things manageable.
This.
And perhaps having less dragon spawns, at least after main quest. I may be good, but it's hard to keep everyone alive when fighting 2 ancient dragons and a blood dragon at the same time. Dawnstar is dragon baited. I've only gone there and not encountered a dragon once. And I've been there a lot. I think I got 15 dragon souls from Dawnstar alone. I don't even care anymore, I've absorbed well over the number I need. Scratch all that, I want a new use for dragon souls. Gimme another perk in Enchant, I don't care. Something to do with all the souls. I'm friggin' Shang Tsung over here with no outlet for my power.