Are there any NPCs in Skyrim your character would call a "true friend"? If so, why?
I find it hard to find friends for my character to make her not feel that alone in this massive world, but since you can't really talk to them except in quests once its kinda hard.
Not really. TES characters are usually flat and two dimensional. I really like the game but my two sons both abandoned it both saying "I don't care about one person in this world. They're all cattle" And of course, if you don't care about anyone, it's hard to care about events. Something Bioware and Rockstar really get better than most, especially Bethesda.
That said, I find if you really RP your character, you can care enough about him/her to keep interest in the events.
My char married Mjoll and that interaction is halfway decent. Mjoll is pretty likeable for an Elder Scrolls char. She's a good spouse and fun to travel/explore with (plus she's an effin beast in combat).