It can be. With just 4 easy steps you can become a unarmed killing machine. (I believe that this is common knowledge, but just in case someone hasn't heard about this playstyle...)
1. Be Khajiit, or at least Argonian, The base damage for unarmed for each race is 4, but for Argonian it's 10 and for Khajiit it's 22
2. Use heavy armor! You need to have heavy armor at least 30 so you can pick a perk named: Fists of steel.
This will make your heavy armor gauntlest give extra damage based on their BASE armor rating.
3. Find the ''Gloves of Pugilist'' from the ratway in Riften. http://elderscrolls.wikia.com/wiki/Gloves_of_the_Pugilist_(Skyrim)
4. Level up your enchanting so you can disenchant the gloves and put the enchantment on your good heavy armor gauntlets and your ring.
Optional preferable steps:
5. Increase smithing and heavy armor as much as possible because you are going to be in close quarters combat the whole time.
6. If you are feeling like a little [censored], you can do the alchemy/enchanting loop for incredible unarmed damage
Please watch this video: http://www.youtube.com/watch?v=uhBiNx749Zw It teaches the same thing as this whole tutorial, but in a very funny way.
