Mhmm.
If I had to pick skills that were the LEAST useful I would say Pickpocketing, speech, and lockpicking... as far as perks go at least.
Every thing else just depends on your build/playstyle.
Are you nuts?
Speech: increase vendors gold is huge plus
Lock picking: double amount of gold and treasure hunter
I agree with pick pocket although I do use the skill that let's me carry another 100 pounds
I spent 20 lvls training my lock picking in order to get treasure hunter.