Depends on your system, and if you have dlcs.
New vegas restored -- Rips down the cell transitions for the strip. Also adds in some buildings.
Sierra madre on the strip. -- Sierra madre is now open for business, on the strip. All sorts of cool things
IWS -- More things to shoot.
Monster Mod -- Lots of different creatures to meet, and kill. (Not at all lore friendly, but it can spice up your game)
Caliber -- A wee bit of work you will have to do to get all everything working properly, but its worth it. New pretty weapons, ammo re-worked.
Eve -- energy weapon mod, currently in a beta, its linked on this forum. Or if your waiting on the next patch, it will appear on nexus for public release on July 11th.
Ghost Variants -- Starcraft ghost armor. Very pretty.
A world of pain -- Lots of new locations with people to kill.
glow sticks -- If you run a weather mod that makes the nights dark, having glow sticks is fun. Or if your in a maze like building having something to drop to mark your passage is nice.
powered power armor -- If you plan on using power armor this adds a real feeling of using advanced tech. Having to maintain your armors power, or looking for sweet upgrades can be fun.