Would free up your cards resources a little bit to be used on something more important. Some people hate jaggies others don't mind I personally use a 2x MSAA or 4x tops. Lowering shadows would buy you some wiggle room as well its all a matter of what you want to sacrifice.
The higher amount of MSAA (multi sampling anti-aliasing) you use, the more dedicated video memory you use. Most forms of anti-aliasing (MSAA, CSAA, SSAA to name a few) require lots of dedicated video memory more than other GPU resources. As long as your GPU has a lot of dedicated memory (1+ GB is a good start), you shouldn't notice much of a drop in frame rate. When your GPU runs out of memory, that's when you can get stuttering and low frame rates. 2x MSAA doesn't use up much memory and unless you have a very low end GPU, it'll have very little effect on your frame rate than if anti-aliasing was off. 4x MSAA takes up quite a bit more memory than 2x. 8x MSAA uses a LOT of memory. You get where I'm going.
FXAA on the other hand takes up very little GPU resources as it's a sort of post process effect on each frame/image. If you think anti-aliasing is affecting your frame rate enough, try FXAA. It doesn't look as good as MSAA in my opinion, but it causes FAR LESS stress on the GPU.
Hope this helps.