You can also start attacking her while she's still talking. It can be very effective, and it cuts short the whole "climb down from the perch, saunter across the room, try to act like a total badass while I get close enough to really hurt you" thing. You know how villains are with their monologuing... if they'd just shut up and get the job done they'd have a much higher percentage of success.
She killed me the first time too, but only because I had no idea that I was going to be kidnapped by the DB when I went to bed that night and had dumped all my armor and weapons in the chest next to the bed. I did not make that mistake a second time. Oh hai there what is this in my hand? Why, I believe if I give it a little shake it will summon a dremora. Really, Astrid, you should try to relax a little and go out drinking once in a while, you never know how beneficial that kind of stress relief will be in the long run.
