Don't forget Travel Light. 1 hour of time saved by running faster per every 10 hours of FNV. I typically have 2x Toughness and the implant so with Reinforced Leather my DT is around 20 for the most part. It's more than I typically need unless I go unarmed/melee. In case it gets problematic I have something heavier hotkey-ed (lately I got even lazier and have a companion carry it for me going for a quick trade when Deathclaws are charging us).
yeah stumbled over travel light pretty late in the game, when i basically already had all perks i considered necessary.
on my next run from scratch, i'll have it in my perk slot for lvl 8, though

i don't take the dt perks, as i'm more the sniper type of player, and leave the style- and honorless clubbing and bashing to others
as mentioned, i'm not reluctant to pump myself full of med-x, slasher, nuka quartz and whiskey. so i can spruce myself up to 22DT/50% DR anytime i want.
being a day tripper and chemist makes that also pretty comfortable, as even the short lasting stuff you can make at a campfire has a reasonable duration then.