Instincts or not, I could be running through a wooded area or down a road and stop at virtually any given location to inspect the area and find an enemy ahead. Enemies abound and the spawn points don't move.
Pretty much this. It's not your instincts from real life kicking in, its your subconscious mind that has a rough idea of how the game is built kicking in telling you that, more than likely, based on your hundreds of hours poured into the game, enemies will be ahead (when aren't enemies ahead most of the time?).