Item Degradation
Let's say you're a level 5 character with 20 points in smithing & one-handed, and you find a glass dagger. For the purposes of this post, give it a blade rating of "advanced". You can use it, but at lower one-handed levels, it degrades faster.
Smithing
At low smithing levels, repairing the glass dagger goes ultra-slow & does not advance your smithing skill as fast as repairing a steel weapon would.
Potions
The use of a potion is tied to your body's adjustment to taking them. There's no skillset involved, just a running count of the potions your body has ingested. Taking a health potion when it gives no effect (ie, you have full health) does not increase their future potency. Think of it like real life proteins, where a high-concentration introduced into a body that's not used to it is wasted. So a 100pt health potion used at a low level might restore 50% of the potion's possible abilities.
Enemies
Skyrim sort of did this right, with Giants and whatnot. The problem is that while the sliding scale works at lower levels, at 26 now I can go almost anywhere. In Morrowind, I was deathly afraid of certain areas and would write down where they were to come back to them at higher levels. The only places I avoided since ~lvl 15 are Giants' camps.
Lockpicking
I could pick expert locks at level 15 with only 1 skill point used in the section. A better way would be to have the current system + turning friction that could break the lock. The higher the lock, the slower it turns with a chance to break even if it's at the sweet spot.
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Half my Skyrim experience have been thoughts of the marketing tachnique "make the game easier so more people will buy it", and that's the wrong signal to send for TES. It's DEFINITELY the wrong signal to send if you want to produce something different and innovative. If voice acting is a cost issue(and in Skyrim, Arnold Schwarzenegger impersonators are everywhere), go back the Morrowind's text system and only use voices for walking by, or introductions or whatnot.

