Do you mean the SM? Because I can't get a quest to start when adding a new branch&node in the SM Change Location (No conditions. Either at the Start of the SM or at the bottom, with Shares event enabled.).
There have been issues reported with Locations (a ways back in this thread, for one place)
So your SM problem MIGHT be related to that, have a look back a couple of pages to try and judge
(and yeah, you are right, it is very difficult to develop when you test your results and aren't sure whether an issue is this bug or your code ... it's a PITA

)
I had some issues when trying to take actions based on mod-added locations, but I haven't had any problems with SM events in general--I have several SM Change Location quests that start properly based on entering vanilla locations, for instance.
Nurgin, I'd suggest trying the absolute simplest case--a quest with no stages, no aliases, just set to "Change Location" in the Event menu of its Quest Data tab and with a simple quest script like:
Scriptname LocChangeTest extends Quest Event OnStoryChangeLocation(ObjectReference akActor, Location akOldLocation, Location akNewLocation) Debug.Messagebox("Change Location!") Stop()EndEvent
If that works, then you can gradually add things until you discover what the problem was. If it doesn't work, then either something is awry with how your SM Event Nodes are setup--do you have any other mods loaded that could be blocking your event from being reached--or, since these bugs seem to be a little variable in who they hit, you could just be unlucky. I agree, it's tough not knowing whether it's your fault or the game's.