Curie, Codsworth, and Nick don't count?
I don't know if you ever played Mass Effect but around the time of Mass Effect 2 the Geth begin to show signs of having free thought when everyone thought they was just machines all with one thought. But as the series progress it showed that they are able to think as individuals and is the main reason the Reapers turned on them.
The point of me bring that up is that I look at their species no different then I look at the other species in the Mass Effect universe but are they human of course not. But they are sentient species just like Human and other aliens.
Snyths might not be human but they are a sentient beings and should be treated no different then humans, none feral ghouls, and none violent/ intelligent super mutants.
Edit- Someone beat me to the Mass Effect example.