Hey Arthmoor,
Very strange, but making a manual save doesn't help. The game is still crashing to the desktop when I try to quit to the menu. Disabling the mod fixes the issue. It can't be a compatibility problem with another mod because as I said before its the only one I've got installed.

Other than that, it is working fine, the alternative starts work properly, the adventurer comes and drops his book etc, I just can't die or quit to the menu
Edit: Maybe this isn't the right place for this but... I have been away from Skyrim for a while, I have just read somewhere that loose files are loaded last now. Does this mean I can safely use the Beth Hi-Res .esp instead of editing the ini to load the .bsa (which at the last time I played was the way to do it). Maybe if I unedited my ini to remove the Beth Hi-Res pack from there and instead ticked the .esp files Live Another Life might work, its the only thing I can think of at this stage.
So question is, is it safe to use the Beth Hi-Res .esp files now, if I download a mod with loose textures will they override the Beth Hi-Res esp files?
2nd Edit: Nope, using the .esp files for the hi-res packs doesn't change the issue. Nevermind, loading and saving games is fine, and I never really quit to main menu anyway or die that often, its just strange nobody else has this problem, especially as I'm on a clean install.