I'm interested in what self-imposed rules you play by. Do you not fast travel? Do you restrict your weapons carrying? What do you do that the game doesn't force you to, but you do it anyway?
Me personally, I restrict my weapons carrying. Depending on what I'm wearing I can only carry a certain number and type of weapon; in Power Armour I have the choice of two long arms, a Minigun/Gatling Laser, or a long arm and a long melee weapon (Shishkebab, Extended Ripper).
If I'm not in Power Armour my options narrow down. I can carry one long arm (which includes the option of a rocket launcher/Fatman) and a sidearm. I can also carry a short melee weapon (Combat Knife, Machete, etc).
Some might think this restrictive, but I find it's an excellent way of balancing my power. It's extremely easy in Bethesda games to carry a weapon for every situation and thus the game becomes extremely easy. By doing this I find that I set myself up one way for what I think I'm going to face, but may end up having to think and adapt on my feet if things don't go the way I think they will. It also means I experience different playstyles depending on how I kit myself out. I can take a suppressed rifle and pistol with a combat knife if I want to be sneaky bastard. If I want to blow some heads off I can grab a heavy sniper rifle and a revolver with a machete. If I really want to [censored] some [censored] up I'll grab a suit of power armour with an extended ripper and go to town on the nearest raider gang, or maybe go all Team Fortress Heavy on the wasteland with a minigun.
I also avoid fast travelling when I can unless there's and in game explanation for an instant travel time. I like to experience every moment my character would.
I also build my settlements with real amenities in mind; bathrooms, kitchens, etc. I like it when they look functional and lived in.
So what do you guys do?