Pretty much anything is better while intoxicated.
Although I would strongly advise against gaming on hallucinogens, don't even try... especially oldschool 8-bit games.
haha... way back in the day me and my buddy did something like that... we managed to beat the original halo on legendary while completely whacked out of our minds... great time... i kept getting lost and wondering backwards through the map and he just kept dying.... but whenever i managed to find my way or i spawned next to him, we seemed to be able to manage... i tell you though, it was intense.... every battle i was gripping the controller like i was trying to crush it in my hands...
i don't think even hallucinogens can stop me from kicking the [censored] out of the original legend of zelda on the NES.... i played that game so much when i was a kid... still to this day i can pick it up and beat it in under 2 hours... well... not the second quest.... that one is insane and always requires some effort.... i can never remember which walls i need to walk through...