Assassin's Creed III, assuming we get a new protagonist/historical setting rather than more Ezio. Also, Soul Calibur V and GTA V (if it comes out this year), but mostly AC3.
are there only sequels coming out? where did all the original games go?
GameStop ate them all. People buy games they know they'll like new, such as games that are parts of franchises they like or very similar to the franchises they like. Original games are risky purchases, since you don't know whether it's any good yet, so people buy them used a week or so after release, denying the publisher and developer from getting any money. You can see why most developers are mostly interested in getting one franchise to be successful and just sticking with it indefinitely.
Edit: Wait, I forgot. Dishonored. Definitely Dishonored.