You're supposed to be irritated by her. Not everyone is going to be nice in the game.
Yeah, because practically everyone in the game is super friendly to you. Nazeem, Delphine, Lilith from Whiterun, thane Erikur from Solitude, Radiant Raiments, the guards, the kids, ...

I hate Maven too and sadly, cannot kill her but I did cause trouble for her.
1: Fail the first few Thieves Guild Questlines (Like burn all Bee hives)
2: Kill Maven's son and daughter (They are killable. Sadly, Maven's husband isn't)
3: Pickpocket Maven's keys (Kinda funny; she wont be able to unlock her house door, if she tries to enter it when you are in Riften)
4: Kill the Leader of the Black-Briar-Meadery (It seems like he supports her)
5: Help the guy who is selling Black-Briar-Mead for very cheap. (He steals her mead thus the money she makes goes down because of him)
6: Kill Frost. (Prolly best option cause this'll effect Maven and the other guy who wanted that horse. That other guy is almost as bad)
Hm. Good ideas you got there. I already did 5 and 6 'though (well, I didn't kill Frost. Besides, can't you just keep the horse by killing that guy?). Does it have any consequences when you fail some TG quests? Well, I'll fail them anyway, I don't want to help Maven in any way. At all.