Plasma Defender doesn't come close to the power of a Hunting Revolver(or its unique variant). And if you have the Cowboy perk, it doesn't come close to the lower tier Lucky or .44 Magnums either. Worst of all, you can't even sneak it into a casino, whereas you can sneak Lucky/.44s in just fine.
Laser RCWs are outclassed by low-tier 10mm SMGs in both damage and crit multiplier.(although the RCW is extremely ammo efficient with its mod... but keep in mind the 10mm SMG is low tier)
