My biggest complaint with playing on 360 was the lack of mods and the insane loading times every time I entered a cell. It was ridiculous, and it ruined the game for me.
I used to play the xbox version only, then I bought the PC version for mods (seeing Jayus Swords on the nexus made me realise I bought the wrong version), whenever I am watching my brother play on his xbox it's so... fugly? Maybe I am too used to my high res modded Skyrim that vanilla just looks barren without distant detail and glorious grasses, along with other goodness.
The load times I never used to notice when I played, but watching my brother I notice them alot more. Weird.