No dude its a QuadroFX 6000 FERMI based on the 480. Please dont post anything you know nothing about it makes you look very stupid. This issue here is happening on Geforces as well. So far turning this option off worked for 3 friends I know of using 480's as well.
Pardon me, I missed post #9 where you stated the model number. The only other Quadro 4GB I knew of was the GTX 280 based one. I have read anecdotal comments in other forums about Fallout 3, recent Nvidia cards and water quality settings. My copy of FO NV will be here today and I'll test it with my GTX 460 1GB. I know its GF104 vs. GF100, but its still based on Fermi. It never had an issue with the previous gen drivers (258.96) and Fallout 3 water - I'll see how 260.89 does with this new game. Also, regardless what you may think about your Quadro just being a GTX 480 while gaming they have a completely different driver set which may not be optimized for gaming. It might have an effect, especially on a new game.