Good Natured is the best, IMO.... way more benefit at the start of the game and it is still useful by the endgame.
I had Trigger discipline on my sniper character and could mow down groups of people with my 12.7mm SMG if they got too close. With fast shot I would probably be reloading the thing every other second.
built to destroy..... I just don't like repairing my gear frequently (FO3....yuck!) and I am VERY accurate with my weapons so killing things usually is no problem what-so-ever.
Small Frame and Four-eyes are pretty darn useful.
I may make a machine-gunner who takes Built to Destroy and Fast shot. Most likely toting a mini-gun.