I will just copy and paste what I put on nexus's forums:

"I found a fix for myself. I remembered using a program that came with Advanced System Care called Game Booster, so i decided to download it again and give it a try. After I started the program I clicked on "configure". I literally checked everything I could in the "configuration" for "services", and "other processes" (in "processes" I left all of my video card, sound card, and mouse processes unchecked), started the program and played skyrim all day without one crash. I have a older Computer, and my guess is it can't handle skyrim and everything else running at the same time. After killing all of the unecessary processes I can play crash free now. Here is a link to get it for free:

http://download.cnet.com/Game-Booster/3000-18512_4-10913645.html

All it does is take a predetermined or user defined list of unecessary processes/programs /services and shuts them down when you start the program before you play a game. This can make a huge difference on older computers like mine. After you are done, you just click to turn it off and it turns the processes/programs/services back on. Very simple, but effective.

I hope this works for you guys. "

-I am now going on 12 hrs of gameplay since I started using this program, and I have not had a single crash. Before I was crashing about every 20-30 minutes. This worked so well for me, that I thought I better share it with everyone here too as I can relate to how frustrating C2D's are;)

Have used Gamebooster for years...I never leave home without it. If nothing else, it does a RAM flush.

Gamebooster too, i also never had any issues with Skyrim.

I tried this software when my character was in one of the many places where the game crash. The result was the same with or without this software. So, if you can try this for me with and without this software, go around Dawnstar and walk to Winter Hold. On my computer, the game crash after one or two minutes.

I never crashed doing it either way. However, as soon as I tried to fast travel to Whiterun with Game Booster off my game crashed. I turned Game Booster back on and fast traveled from the exact same spot and didn't crash. What are your system specs? It appears to me that this game is pretty demanding, not just on GPU, but on CPU and RAM as well. So anything you can do to minimize this load can in theory help. Try looking at some of the FPS Tweak guides, TESV acceleration layer (requires SKyrim Script Extender or SKSE), and also play around with reducing your graphics settings (reducing AA, AF, Texture Quality, Fade Distances etc.) Make sure you have latest GPU drivers, computer is defraged, etc.
Another thing you can try is to reinstall your .ini files. Go to Documents/MyGames/Skyrim and then delete Skyrimprefs.ini and Skyrim.ini. Then go to Computer/Local Disk C:/Program Files/Steam/steamapps/common/skyrim/skyrim (yes there are two skyrim directories) and finally delete the other skyrimprefs.ini. After you have deleted those, open up steam, right click on skyrim in your library, select properties/local files/verify integrity of game cache (this will re-download and install your .ini files from scratch. You will have to go through your video settings again though as they will get reset to the recommended default settings the next time you start your game.

i Use the Advanced System care software too never tryed the gameboost will have to have a look

I prefer GBoost.

LOL. Skyrim crashed only twice on my PC. Both times i had Gamebooster running in the background. No crashes without it.

Meh, probably okay software to help low-end computers but since about winXP SP1 there's been good reasons to not just arbitrarily turn off services or a need to balloon-flush ram and I don't really like the thought of random 3rd party 'free' software that claims to optimize things...there is always a catch, no exceptions. (except specific game mods like skyboost, they're cool )

Wha?

Anyway, all it is is a quick easy way to turn off services you KNOW you don't need, with a click of a button. There's no catch. I've been using it many months now. But I haven't noticed any real difference with my games, I just use it for the hell of it.

*thatsthejoke.jpg*

and you're right if you know what the service is and know nothing depends upon it then sure turn the thing off, but giving up that sort of control to some random software is not a very appealing situation and with the advent of things like quadcore CPUs and the like there is pretty much very little to gain from such tiny little changes for modern systems.

I've tried it and it didn't make any difference for me.It just closes some background stuff and frees up some RAM witch i have plenty of anyways.

when you are maxed @ 4gb for Skyrim, every ounce of RAM away from the system is precious...those extra 8 you have don't really help this game

Yeah, it's mostly for little baby machines. But it makes me feel a little better when I use it, anyway.

Cool gonna give that a try

@am1590 :

I have a pretty good configuration, i think this is not the problem :

Nvidia GTX 580 1,5Go
DDR 3 8Go 1866Mhz
I7-2600k 3.4Ghz

My computer is recent, i bought it on october, just for Skyrim. So, on it, little software are installed, in fact, just Steam, Skyrim, The Witcher 2, Origin and Battlefield 3. This computer is only for video game, so it's totaly safe (not acces on internet except for Steam and Origin. The drivers, mods and others are downloaded on my linux computer) and defraged (not files transfert on the hard drive exept the mods). At level of my drivers, my graphical card has the last bêta driver (290.53), except her, i think no component need a specific driver.

Actually, i use many mod for HD textures (3,5 Go) and SkyBoost and ENB 0.96, but, my game is more stable than before installation of these mods. For example, before i use Skyboost, my character could not go to Riften and now he can. I played without any mod during fourty hours and the game crashed more than now with many mods (70 hours). I uninstalled the game, the mod, the ini files and all files about Skyrim on my hard drive for each new official patch then i played few hours without any modificiation then, finally, i played few hours with many modifications and the result is the same at each once, my game is more stable with ini tweaks and HD textures, ENB and, recently, with SkyBoost, than the official version.

But here's the thing: Those services and background processes etc that program is turning off aren't enfringing upon that. Keep this in mind: Skyrim ie tesv.exe can use up to 4GB of system memory, but everything else uses other chunks of the system memory and they don't overlap (unless you're running enough stuff that with everything combined its exceeding the total). So yah remember there's a very clear distinction between 'total available' and 'total that be allocated to each particular process that's running'. Skyrim gets to use upto 4gb, and if firefox is also running for more then 20 minutes it gets to eat its own 4gb chunk of your system memory but they're independent.

/I exaggerated on the firefox mention, it'd be at least 26 minutes to reach 4gb consumed

so in turning off the other background processes, those that are unnecessary for anything but bare windows and the game, it is only freeing up CPU power, but not really RAM if you have, say 12 or 16mb to begin with? ahhhh.

Aye and far as CPU needs go, a quadcore like ours I can assure you is not being adversely affected by some service that runs a system call once every few minutes to keep itself awake or the what not. I mean take my 'fight with 50 drunks' example:
http://img849.imageshack.us/img849/6788/skythread03angrydrunks.jpg

That's about 40 more NPCs in a fight then you'll find in most vanilla situations and there's still *lots* of room to spare. Your comp is rockin', turn off the malware hidden in sheep's clothing. Because if its not malware yet it will be the second some bigger fish notices its install base, buys it and then starts abusing it to generate money.

Don't be so paranoid. It is not the devil Bobby Boucher! It is made by Iobit, and gets 4.5-5 star reviews on CNET. It is not or will not ever be malware. There is no catch, it is free. It keeps my game from crashing, and that is a fact- so to say it does nothing is a lie. If it helped me then it might help others so it is at least worth trying if you are crashing to desktop in skyrim. If not you can always uninstall the program;)

Hope you aren't actually downloading it through Cnet's methods, otherwise you just proved my point.

Skyrim rarely if ever uses more than 2gb of ram, even with texture mods and all that. If you've got 4gb of ram and gameboost is helping your performance, you probably have a bigger underlying issue (possibly malware)

Start->run>msconfig: you can disable all that stuff there too.

Boy you are full of opinions, but I see no proof in your paranoia. Exactly how is Game Booster malware??? I want facts, links, references.

Well, he isn't being paranoid about Gamebooster per se (I think), but that if you get the game from some 3rd party site it is very easy to get alot crap on your computer that just negated any benefit the program was going to bring. 3rd party sites like cnet (but there are many others) have their own 'loaders' that are full of crap and malware, and purposely deceptive "DOWNLOAD" buttons next to the actual file you want...so if you aren't careful, you've just added some brutal new toolbar to your browser.

I like Gamebooster (actually I love it) but I think Bump has a point about the WAY in which many people acquire this kind of software.