Guns are more versatile and easy to use because of their ubiquity. For my second playthrough, however, I decided to try a different playstyle by using energy weapons. I won't lie; for the first half of the game I regretted my choice because of the lack of variety and ammo, but I stuck through it and am pleasantly surprised at how easy the game can be on Very Hard difficulty--hardcoe turned on. This may be partly due to the fact that I have already played through the game but I really do believe that with the right perks and a really high Luck stat, you can kick serious butt.
I'm going to go ahead and put in a modest example of how neat the Laser RCW is (warning: spoiler for Boone's quest): http://www.youtube.com/watch?v=ePpMG2Evbb8 . When playing through this quest in my first playthrough with a Guns-focused character, it took much longer to take out the Legion soldiers at a similar level. Shortly after this I went after the Deathclaws in Quarry Junction and also had an easier time wittling down their health.