I took the DB out fairly soon on my 1st character and joined them fairly early on on my 2nd one, but I'm sure I pissed a few people off before I got around to those two points. 
FWIW: in Fallout 3 I had plenty of Talon Co come after me.

Strange. This game has to be the most "variable" one I've ever played. On nearly every toon I've played more than just a level or two, I've had assassins out of NOWHERE - by level 3.... and continuing. Now, believe me, I haven't ever done ANYTHING TO ANYONE at level 3 - bandit extermination, draugr wiping.... that's it. Haven't been near Riften. Haven't TOUCHED the TG or DB. Haven't even done the MQ starters. But EVERY toon has to fend off assassins.... every one of whom is carrying that note signed by Astrid.... And you wonder WHY I choose later to wipe out the DB?


