Sniper rifle fully modded
10mm Pistol fully modded
12.7 Pistol
Frag grenades
Frag mines

1st Recon Beret
Recon armor

i meant that the all american is effective at guns skill 100. im not sure what it means if u use weapons when ur skill isnt high enough.

Sniper Rifle with carbon fiber parts and sliencer (my favorite gun in the game, i can take out a whole town and nobody knows i was even there)
12.7mm pistol slienced
lightmachine gun with expanded drums
x2 frag, pulse, and plasma grenades
mark 2 combat armor

Just means you use a small bit of effectiveness that all.

I ended the game with:

1st Recon Beret
Reinforced combat armor mk2
Sunglasses
Plasma rifle

I had a lot of other guns on me but I ended up using the plasma rifle to win.

My companion Veronica had:

Displacer Fist / Ballistic Fist
T51B Power Armor
Combat helmet

Level 13.

Alien Blaster
This Machine
Chance's Knife
Assault Carbine
Sniper Rifle

Chinese Stealth Armour (for travelling) and Reinforced Combat Armour Mark II for battles
Reinforced Combat Helmet Mark II
Rebreather

Pretty good seyup, but I think I missed out one or two guns.

I'm afraid I can't remember what level I'm at, I think it's 16?

Casual Gear:

Pre-war Hat
Sunglasses
Benny's suit

Casual Weapon(s):
10mm pistol
Power Fist

Combat Gear:

Pre-war hat or 1st Recon Beret
Sunglasses
Reinforced combat armor mark II

Combat weapon(s):

Power Fist
Sniper Rifle
10mm pistol

Headwear: Fire Helmet #1
Eyewear: Authority Shades
Body: Combat Armour/Advanced Radiation Suit
(good combo: all matching black)

Weapons:
- Weathered 10mm Pistol (useful for most lower-tier enemies)
- 10mm SMG fully modded
- Hunting Shotgun (concentrated damage - have yet to test beanbag rounds)
- Frags and Dynamite (throw and forget)
- Modded Cowboy Repeater (for mid to long range sniping on-the-fly)
- Fire Axe recently swapped by Knock-Knock (awesome weapon: has high DMG/DPS and looks appealing)
- that Q-something-Modulator, Multiplex Rifle

Level 15
Lucky (.357 magnum)
10mm pistol with silencer and laser sight
Hunting Rifle with scope and extended mags.
Combat Knife

Generally carry 50 shots per gun when traveling to cut down on weight.

As far as clothing,
Bounty Hunter Duster
Sunglasses
Jessup's Bandanna

Level 21

Vault 34 Security Armor
First recon beret

Recharger Rifle (for pests)
This Machine (M1 Garand) Long range
Alien Blaster (For the biggest adversaries)
Hunting Revolver or 12.7 Pistol when I have ammo for close up dangerous foes
That Gun when I lack ammo for the above
Cowboy Repeater for Medium Range or sometimes the AER14 Laser Rifle
Grenade Launcher for approaching Cazadores
Matter Manipulator
All American
Pulse Gun for robots

I typically don't use shotguns and I just acquired the Gauss Rifle but haven't repaired it up yet. I'm still stockpiling weapon repair kits.

The 12.7 pistol got me through Vault 34 with those super gouls. I gave the AntiMaterial rifle to Boone with carefully rationed ammunition. The cowboy repeater and the Weathered 10mm got me through the early levels.

Level 30

1. Gobi Sniper Rifle for my long range, even mid-range needs
2. Light Machine Gun
3. All-American for clearing buildings
4. Riot shotgun for large numbers of enemies
5. Pushy
6. Heavy Incinerator for when I want to set things on fire
7. YCS/186 for my flashy kills