I think he's alluding to using the restoration exploit that lets you make potions that can fortify skills by several billion points;so you can smith weapons that do millions of damage; or a fortify marksman potion that makes every arrow do billions of damage, without ever gaining a level in their governing skills.

Cause even as a glitch, similar effects can be performed with weakness to magic potions which has the same effect if you stack them.
You don't need exploits. You can easily reach 6000+ damage in one melee attack without ever getting into that loop. Make a fortify smithing/enchanting potions, then smith and enchant your armor and weapons, and that's it.
Mages can do 1500 per attack, if they constantly stop the game, enter the menu and clung potions, and if they have the necessary gear. Melee can do 6000+ per hit (without even sneak, then they can easily do 36000+) WITHOUT ever stopping the game to use potions in battle.
The arguement that "damage over 1000 means little, over 6000 means nothing" is invalid. Yes, the difference between 1500 and 6000 means little when the enemies die in less than that, but the difference between 100 and 400 that exists earlier in the game does mean a lot... because apart from the first few levels, the gap between destro and the other damaging skills is always ENORMOUS. Yes, until you get the final talents, archery makes yu slow in combat and melee always forces you to be close to the target... however, until you get high enough enchantment, destruction spells drain your mana far before you manage to kill even the lowliest draugr, and before you get impact the enemies kill you before you can slay a single one of them.
Destruction is just underpowered. And no, to the one who said that, it's not the other skills that are op. When everything in a category of skills is more or less balanced, except for the one skill that is stronger/weaker, it's obvious that the normal is everything else appart from the odd one.
Archery, 1-h and 2-h are pretty viable from early one, and become very powerful with minimal effort at high levels, as one would expect from any rpg class/skill. Even conjuration, that is a hybrid damage/support skill, is the same. But destruction is only viable early on, unless you exploit one the game's major flaws, and even then it's only virtue compaired to the others is it has unlimmited "ammo"... It is also very limited, when weapons are fully customisable from parylisation to soul absorbsion (and that is another interesting fact: Beth didn't remove spellcrafting - they just placed it in the wrong spot XD)
Also, the difference between destro damage and the rest is so big that makes any "DPH =/= DPS" arguement invalid.