Essentially NPCs should be able to calculate their chance of death and avoid it, they can flee or persuade or attract help. Death should be used sparingly, incapacitating, taking prisoner instead of killing should be a higher priority by hostile NPCs. Not everyone is an outright murderer, most will mercy. Radiant story can create a rescue mission then. So many possibilities...
And I would never go on a killing spree. I play good guys.
But in 1000 hours, if I ever decide to kill one person, first and last, then I want to be able.

