I love mods for New Vegas and I can't imagine playing without them.
I have a 1:3 perk ratio, I got no health per level up, I have random encounters back in the game, I have classical Fallout weapons back, I can use hardcoe Mode without those annoying Survival meters, I made my own gang mod that adds several new groups of gangs to the gameworld, I had mods to make Melissa and Marcus companions with fitting dialogue for it, I added more map markers to inner Vegas so I don't have to walk from the gate to Van Graffs for example, I added in my own Legionnairy Survival Vendor, I added two bounty hunter mods for roleplaying reasons, I have Sunny and Cheyenne as companions for early game, I made caps and chems have their own weight, I can have as many companions as I want to, I don't get dialogue hints to speech checks, I got a mod that expanded Goodsprings so that it has more flesh to it, I have Chet as a repair-man, and more.
Seriously, mods are great.
You just need to figure out which ones are needed for your gameplay and get the perfect set-up.
My game is not a mess nor any more buggy than what it was at vanilla stage
And now the game works the way "I" want it to work.