1. Deadric Bow (Legendary)
2. Ebony Sword (Legendary)
Draught of Healing
Fire Breath
Beast Form

I'm on PS3

I don't use any hotkeys. Why am I playing on the PC, again? Oh, right...

Blizzard
Bound Bow
Clairvoyance
Clear Skies(alternative for Unrelenting Force)
Close Wounds
Conjure Dremora Lord
Conjure Frost Atronach
Dragonrend
Fire Breath
Fire Storm
Fireball
Frost Breath
Heal Other
Ice Storm

dual weapons (or single), bow, unrelenting force, marked for death, slow time, night eye (if available), dagger (if sneaky), spells (if mage)

duals abd bow as 1 and 2

360

1. Fire spell/ Sword.
2. shield.
3. Bow.

PC here:

1. Fav sword (Dragonbane)
2. Unenchanted hand-axe
3. Two hand weapon (varies, but currently a mod dai katana)
4. Shield
5. Offensive spell (varies, but generally fireball or thunderbolt)
6. Utility spell (usually candlelight or soul trap)
7. Healing spell (grand healing)
8. Shout (standard is dragonrend, but I do change it according to circumstance)

I tend to reorganize my 8 keys based on character type, development, and surroundings/enemies. Like if I know I'm gonna encounter undeads, I'll bind weapons that defeat them and spells that detect undead. If playing a mage I won't carry any weapons. If having shouts I may bind some of those (throw voice, sprint, whatever suits my character). I have no fixed system, except weapons and healing on the first three, and powers on the last one or two.